Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL866942 | 0.96 | ALDH1A1 (0.93) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| SCHEMBL5098171 | 0.96 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| SCHEMBL5098181 | 0.96 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| SCHEMBL2048901 | 0.96 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| SCHEMBL15617 | 0.96 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| Methacrylic Acid SCHEMBL28593113 | 0.95 | ALDH1A1 (0.89) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| Methacrylic Acid SCHEMBL180731 | 0.95 | ALDH1A1 (0.89) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| Methacrylic Acid SCHEMBL21811332 | 0.95 | ALDH1A1 (0.89) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| Methacrylic Acid SCHEMBL6743789 | 0.95 | ALDH1A1 (0.89) | ALDH1A1CYP3A4TP53TSHRTHRB | |
| Benzene SCHEMBL7777595 | 0.95 | ALDH1A1 (0.89) | ALDH1A1CYP3A4TP53TSHRMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464209-B2 | Container coating compositions | PPG INDUSTRIES OHIO, INC. (US) | 2016-10-11 | — | — | US | claimed |
| EP-3060618-A1 | CONTAINER COATING COMPOSITIONS | PPG Industries Ohio, Inc. (US) | 2016-08-31 | — | — | EP | claimed |
| WO-2015061309-A1 | CONTAINER COATING COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2015-04-30 | — | — | WO | claimed |
| US-20150110981-A1 | CONTAINER COATING COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2015-04-23 | — | — | US | claimed |
| US-6248860-B1 | BEFORE BECOMING CROSS-LINKED, COMPRISED ALKYLENE CARBONATE UNITS HAVING SUBSTITUENTS WITH TERMINAL MOIETIES SELECTED FROM THE GROUP CONSISTING OF TERMINAL ALKENYL MOIETIES AND TRIALKOXYSILANE MOIETIES. | EMPOWER MATERIALS INC. | 2001-06-19 | — | — | US | claimed |
| US-9464209-B2 | Container coating compositions | PPG INDUSTRIES OHIO, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| EP-3060618-A1 | CONTAINER COATING COMPOSITIONS | PPG Industries Ohio, Inc. (US) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061309-A1 | CONTAINER COATING COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2015-04-30 | — | — | WO | disclosed |
| US-20150110981-A1 | CONTAINER COATING COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2015-04-23 | — | — | US | disclosed |
| EP-1629055-B1 | COATING COMPOSITION COMPRISING A WATER-DISPERSIBLE, POLY-ELECTROLYTE FREE BLOCK COPOLYMER AND A CROSS-LINKING AGENT, CURED FILM THEREOF AND LAYERED SYSTEM COMPRISING THE SAME | BASF CORP (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1629055-A1 | COATING COMPOSITION COMPRISING A WATER-DISPERSIBLE, POLY-ELECTROLYTE FREE BLOCK COPOLYMER AND A CROSS-LINKING AGENT, CURED FILM THEREOF AND LAYERED SYSTEM COMPRISING THE SAME | Basf Corporation (US) | 2006-03-01 | — | — | EP | disclosed |
| US-6881791-B2 | Noncracking, wear resistance; crosslinked block addition polymer; paint | BASF CORPORATION (US) | 2005-04-19 | — | — | US | disclosed |
| EP-0889103-A2 | Carbamate-functional polymer composition | BASF CORPORATION (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1999000444-A1 | FUNCTIONALIZED POLY(ALKYLENE CARBONATE), AND USE THEREOF | PAC POLYMERS INC. (US) | 1999-01-07 | — | — | WO | disclosed |
| WO-1997023516-A1 | AQUEOUS CROSS-LINKABLE COATING COMPOSITION | THE VALSPAR CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |
| EP-0349874-B1 | A new and improved method for the preparation of cross-linked polycarbonates, and compositions made therefrom | GEN ELECTRIC (US) | 1994-08-31 | — | — | EP | disclosed |
| US-5124407-A | Crosslinkable compositions comprising cyclic polycarbonates and glycidyl group-containing copolymers | GENERAL ELECTRIC COMPANY (US) | 1992-06-23 | — | — | US | disclosed |
| US-5115024-A | Heating a cyclic polycarbonate oligomer and a glycidyl acrylate copolymer in the presence of a polycarbonate formation catalyst | GENERAL ELECTRIC COMPANY (US) | 1992-05-19 | — | — | US | disclosed |
| US-4916189-A | WITH A GLYCIDYL ACRYLATE COPOLYMER | GENERAL ELECTRIC COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0349874-A2 | A new and improved method for the preparation of cross-linked polycarbonates, and compositions made therefrom | GENERAL ELECTRIC COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |