Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494089 | 0.97 | PDCD1 (0.34) | PDCD1CD274CHRNB2CHRNA4BRD4 | |
| SCHEMBL8468224 | 0.95 | PDCD1 (0.33) | PDCD1CD274CHRNB2CHRNA4BRD4 | |
| SCHEMBL27459241 | 0.91 | PDCD1 (0.31) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL7009427 | 0.88 | PDCD1 (0.34) | PDCD1CD274CHRNB2CHRNA4BRD4 | |
| SCHEMBL8469757 | 0.88 | — | — | |
| SCHEMBL8469760 | 0.88 | — | — | |
| SCHEMBL7053629 | 0.86 | PDCD1 (0.39) | PDCD1CD274CHRNB2CHRNA4BRD4 | |
| SCHEMBL27498413 | 0.85 | MAOB (0.35) | — | |
| Hydrochloric Acid SCHEMBL27550862 | 0.84 | GSTP1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL20480854 | 0.84 | BRD4 (0.32) | PDCD1CD274CHRNB2CHRNA4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247686-B2 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | BASELL POLYOLEFINE GMBH (DE) | 2007-07-24 | — | — | US | disclosed |
| EP-1442067-B1 | SOLID COCATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST SYSTEM THEREOF | SUNALLOMER LTD (JP) | 2007-04-18 | — | — | EP | disclosed |
| CN-1289536-C | Oleifin polymerization catalyst, catalyst component for olefin polymerization, method of storing these, and process for producing olefin polymer | SUNALLOMER LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| CN-1612900-A | Solid cocatalyst component for olefin polymerization and catalyst system thereof | SUNALLOMER LTD (JP) | 2005-05-04 | — | — | CN | disclosed |
| US-20050009689-A1 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | SUNALLOMER LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| CN-1481394-A | Olefin polymerization catalyst, olefin polymerization catalyst component and method for storing the same, and process for producing olefin polymer | 胜亚诺盟股份有限公司 | 2004-03-10 | — | — | CN | disclosed |