Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 13/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389665 | 0.85 | GPR119 (0.50) | NAMPT | |
| SCHEMBL391327 | 0.72 | NAMPT (0.53) | NAMPT | |
| SCHEMBL4168814 | 0.71 | PIM1 (0.60) | NAMPTNPC1ALDH1A1HPGDPIM1 | |
| SCHEMBL2566220 | 0.68 | PIM1 (0.46) | NAMPTNPC1ALDH1A1RAB9APIM1 | |
| SCHEMBL5306565 | 0.68 | TSHR (0.42) | NAMPTNPC1ALDH1A1RAB9A | |
| SCHEMBL3672386 | 0.68 | CHRM2 (0.39) | NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5133930 | 0.68 | NAMPT (0.39) | NAMPTNPC1ALDH1A1RAB9ADRD2 | |
| SCHEMBL2916873 | 0.67 | PIM1 (0.44) | NAMPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL27769053 | 0.66 | DRD4 (0.36) | NAMPTHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL1073075 | 0.66 | POLB (0.40) | ALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |