Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172899 | 0.86 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL5172311 | 0.85 | MAPT (0.66) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL5171022 | 0.82 | MAPT (0.58) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5171459 | 0.81 | MAPT (0.51) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL630624 | 0.80 | MAPT (0.65) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL6152116 | 0.76 | KMT2A (0.74) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5171421 | 0.76 | MAPT (0.63) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL19392315 | 0.75 | MAPT (0.77) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL3568215 | 0.74 | KMT2A (1.00) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL2208450 | 0.74 | AKR1C3 (0.68) | MAPTKDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |