Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225920 | 1.00 | SIGMAR1 (0.47) | SIGMAR1HDAC1HDAC8HDAC6HTR2A | |
| SCHEMBL4225925 | 1.00 | SIGMAR1 (0.47) | SIGMAR1HDAC1HDAC8HDAC6HTR2A | |
| SCHEMBL4229392 | 0.94 | KAT2B (0.45) | SIGMAR1HDAC1HDAC8HDAC6LTA4H | |
| SCHEMBL4229385 | 0.94 | KAT2B (0.45) | SIGMAR1HDAC1HDAC8HDAC6LTA4H | |
| SCHEMBL5169589 | 0.91 | HDAC1 (0.53) | SIGMAR1HDAC1HDAC8HDAC6HTR2A | |
| SCHEMBL4217268 | 0.91 | HDAC1 (0.53) | SIGMAR1HDAC1HDAC8HDAC6HTR2A | |
| SCHEMBL1707549 | 0.91 | CNR1 (0.41) | SIGMAR1DRD2DRD4OPRM1JAK1 | |
| SCHEMBL1706860 | 0.91 | SIGMAR1 (0.38) | SIGMAR1HDAC1HDAC8HDAC6HTR2A | |
| SCHEMBL1707552 | 0.91 | CNR1 (0.41) | SIGMAR1DRD2DRD4OPRM1JAK1 | |
| SCHEMBL1706862 | 0.91 | SIGMAR1 (0.38) | SIGMAR1HDAC1HDAC8HDAC6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |