Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920875 | 0.86 | COMT (0.35) | COMT | |
| SCHEMBL16799213 | 0.77 | — | — | |
| SCHEMBL2247946 | 0.74 | — | — | |
| SCHEMBL248319 | 0.74 | — | — | |
| SCHEMBL12712809 | 0.69 | MEN1 (0.46) | COMT | |
| SCHEMBL7357687 | 0.68 | ANPEP (0.34) | — | |
| SCHEMBL1515411 | 0.68 | TRPA1 (0.30) | — | |
| SCHEMBL27987036 | 0.67 | — | — | |
| SCHEMBL24738190 | 0.67 | COMT (0.37) | COMT | |
| SCHEMBL15447909 | 0.67 | MEN1 (0.50) | COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101001851-B | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC | 2011-04-20 | — | — | CN | disclosed |
| CN-101001851-A | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |