Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28253909 | 0.80 | KDM4E (0.50) | KDM4ENPSR1LMNAHPGDCA12 | |
| SCHEMBL239971 | 0.80 | KDM4E (0.50) | KDM4ENPSR1LMNAHPGDCA12 | |
| SCHEMBL16868500 | 0.78 | KCNA5 (0.59) | KDM4ENPSR1LMNAHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL11409053 | 0.78 | KDM4E (0.48) | KDM4ENPSR1LMNAHPGDMEN1 | |
| SCHEMBL13043277 | 0.78 | KDM4E (0.48) | KDM4ENPSR1LMNAHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL29269084 | 0.78 | KDM4E (0.48) | KDM4ENPSR1LMNAHPGDMEN1 | |
| SCHEMBL7533388 | 0.76 | KCNA5 (0.58) | KDM4ENPSR1LMNAHPGDMEN1 | |
| SCHEMBL730299 | 0.76 | CA9 (0.48) | KDM4ENPSR1LMNAHPGDCA12 | |
| Hydrochloric Acid SCHEMBL28020743 | 0.76 | KCNA5 (0.58) | KDM4ENPSR1LMNAHPGDMEN1 | |
| SCHEMBL3076601 | 0.74 | KDM4E (0.50) | KDM4ENPSR1LMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946183-B1 | USE OF PYRIDAZINONE OR PHOSPHINE OXIDE COMPOUNDS TO TREAT OR PREVENT CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 2007-05-02 | — | — | EP | claimed |
| EP-0946183-A4 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 2001-07-18 | — | — | EP | claimed |
| JP-2001503413-A | — | — | 2001-03-13 | — | — | JP | claimed |
| EP-0946183-A1 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | claimed |
| US-5935945-A | ADMINISTERING PHOSPHINE OXIDE COMPOUND WHICH BLOCKS RAPIDLY ACTIVATING DELAYED RECTIFIER POTASSIUM ION CURRENT OF THE ATRIUM | MERCK & CO., INC. (US) | 1999-08-10 | — | — | US | claimed |
| WO-1998018476-A1 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0946183-B1 | USE OF PYRIDAZINONE OR PHOSPHINE OXIDE COMPOUNDS TO TREAT OR PREVENT CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-0946183-A4 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6214809-B1 | ANTIARRTHYMIA AGENTS | MERCK & CO., INC. | 2001-04-10 | — | — | US | disclosed |
| EP-0946183-A1 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935945-A | ADMINISTERING PHOSPHINE OXIDE COMPOUND WHICH BLOCKS RAPIDLY ACTIVATING DELAYED RECTIFIER POTASSIUM ION CURRENT OF THE ATRIUM | MERCK & CO., INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998018476-A1 | METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | disclosed |