SCHEMBL5170362

SCHEMBL5170362

CN(CC(=O)c1ccccc1)Cc1ccc(C(C)(C)C)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.54
TMEM97 Q5BJF2 1/20 0.54
ESRRG P62508 1/20 0.50
NR1H4 Q96RI1 2/20 0.48
RAB9A P51151 5/20 0.48
KMT2A Q03164 2/20 0.48
MEN1 O00255 1/20 0.48
LMNA P02545 2/20 0.48
NR1I2 O75469 1/20 0.48
ADRA2A P08913 1/20 0.48
CYP2D6 P10635 1/20 0.48
ACHE P22303 1/20 0.48
SLC6A2 P23975 1/20 0.48
HTR2A P28223 1/20 0.48
SLC6A4 P31645 1/20 0.48
KCNH2 Q12809 1/20 0.48
PTGES O14684 1/20 0.47
ALOX5 P09917 1/20 0.47
NPC1 O15118 3/20 0.47
ALDH1A1 P00352 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5166526 0.99 SIGMAR1 (0.53) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL5166698 0.92 SIGMAR1 (0.51) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL6249114 0.90 NR1H4 (0.54) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL6249120 0.87 MAPT (0.60) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL13889650 0.86 KMT2A (0.55) RAB9AKMT2AMEN1ACHENPC1
SCHEMBL6249909 0.86 MAPT (0.52) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL6248136 0.86 TMEM97 (0.46) SIGMAR1TMEM97ESRRGNR1H4RAB9A
SCHEMBL5182136 0.86 MEN1 (0.55) SIGMAR1TMEM97NR1H4RAB9AKMT2A
SCHEMBL5169846 0.85 KCNK3 (0.48) SIGMAR1TMEM97ESRRGNR1H4RAB9A
Hydrochloric Acid SCHEMBL28169240 0.84 SMN1; SMN2 (0.56) RAB9AKMT2AMEN1LMNAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP claimed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US claimed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP claimed
EP-1561744-B1 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEM IND INC (JP) 2007-04-18 EP disclosed
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP disclosed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US disclosed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP disclosed