Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169287 | 0.81 | POLB (0.47) | TSHRPOLBKMT2AEZH2HTT | |
| SCHEMBL630660 | 0.80 | TSHR (0.57) | TSHRPOLBKMT2ARCE1EZH2 | |
| SCHEMBL8738291 | 0.79 | EZH2 (0.69) | TSHRPOLBKMT2AEZH2MEN1 | |
| SCHEMBL8268040 | 0.79 | TSHR (0.59) | TSHRPOLBKMT2ARCE1EZH2 | |
| SCHEMBL5173273 | 0.79 | SMN1; SMN2 (0.47) | TSHRPOLBKMT2AHTTMEN1 | |
| SCHEMBL15613235 | 0.76 | TSHR (0.79) | TSHRPOLBKMT2ARCE1EZH2 | |
| SCHEMBL5173129 | 0.74 | GLA (0.57) | POLBKMT2AMEN1MAPT | |
| SCHEMBL630659 | 0.70 | TSHR (0.43) | TSHRPOLBKMT2ARCE1EZH2 | |
| SCHEMBL5170755 | 0.70 | TSHR (0.54) | TSHRPOLBKMT2ARCE1EZH2 | |
| SCHEMBL30335624 | 0.70 | POLB (0.77) | TSHRPOLBKMT2AEZH2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |