Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630659 | 0.85 | TSHR (0.43) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL5173124 | 0.77 | ALDH1A1 (0.38) | POLBPKMGAA | |
| SCHEMBL631683 | 0.75 | MEN1 (0.45) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL6166781 | 0.74 | GAA (0.48) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL15613235 | 0.72 | TSHR (0.79) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL630660 | 0.71 | TSHR (0.57) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL8268040 | 0.70 | TSHR (0.59) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL5170764 | 0.70 | TSHR (0.59) | TSHRPOLBMEN1MAPTRECQL | |
| SCHEMBL8738291 | 0.68 | EZH2 (0.69) | TSHRPOLBMEN1KMT2AEZH2 | |
| SCHEMBL630790 | 0.67 | GLA (0.53) | POLBMAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |