Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ERG | P11308 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170526 | 0.86 | KCNH2 (0.33) | SLC18A2 | |
| SCHEMBL5170856 | 0.86 | PPARD (0.38) | S1PR1PPARDPPARASLC18A2 | |
| SCHEMBL5171675 | 0.85 | PANK3 (0.39) | PRMT5WDR77PANK3PPARDPPARA | |
| SCHEMBL5170835 | 0.84 | GPR52 (0.41) | GPR52PRMT5WDR77PANK3S1PR1 | |
| SCHEMBL5173434 | 0.83 | KDM4C (0.35) | SLC18A2 | |
| SCHEMBL5170925 | 0.81 | POLB (0.36) | SLC18A2 | |
| SCHEMBL5170769 | 0.81 | SLC18A2 (0.33) | SLC18A2 | |
| SCHEMBL2120757 | 0.80 | PPARD (0.39) | PPARDPPARASLC18A2 | |
| SCHEMBL5170176 | 0.80 | SLC18A2 (0.36) | SLC18A2 | |
| SCHEMBL5183241 | 0.79 | HRH3 (0.33) | GRM2SLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |