Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | STAT1 | P42224 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | SMO | Q99835 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983716 | 0.87 | MEN1 (0.61) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4983710 | 0.87 | MEN1 (0.61) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27700978 | 0.86 | MEN1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27700976 | 0.86 | MEN1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4982097 | 0.81 | S1PR1 (0.68) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4982107 | 0.81 | S1PR1 (0.68) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14106378 | 0.79 | KMT2A (0.69) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14457064 | 0.77 | MEN1 (0.73) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4979410 | 0.76 | RAB9A (0.50) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4979402 | 0.76 | RAB9A (0.50) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781595-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | Praecis Pharmaceuticals Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006020951-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | PRAECIS PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |