Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13767970 | 0.79 | TP53 (0.44) | TP53TSHRL3MBTL1ALDH1A1HPGD | |
| SCHEMBL10130574 | 0.78 | KDM4E (0.43) | KDM4ETDP1L3MBTL1CES2CES1 | |
| SCHEMBL13767971 | 0.78 | TP53 (0.43) | TP53TSHRALDH1A1HPGD | |
| SCHEMBL5972869 | 0.78 | CES2 (0.35) | KDM4ETDP1L3MBTL1CES2CES1 | |
| SCHEMBL24311836 | 0.78 | CES2 (0.35) | KDM4ETDP1L3MBTL1CES2CES1 | |
| SCHEMBL24312307 | 0.77 | KDM4E (0.35) | KDM4ETDP1L3MBTL1CES2CES1 | |
| SCHEMBL5147000 | 0.75 | KDM4E (0.41) | TSHRKDM4ETDP1L3MBTL1CES2 | |
| SCHEMBL10387818 | 0.75 | KDM4E (0.41) | KDM4ETDP1ALDH1A1 | |
| SCHEMBL11200328 | 0.75 | TP53 (0.61) | TP53TSHRKMT2A | |
| SCHEMBL6641492 | 0.75 | KDM4E (0.41) | KDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784400-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006023462-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-03-02 | — | — | WO | disclosed |