Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398801 | 0.90 | IGF1R (0.62) | IGF1RTNK2CYP2C9 | |
| SCHEMBL399766 | 0.80 | IGF1R (0.59) | IGF1RTNK2CYP2C9 | |
| SCHEMBL402609 | 0.75 | IGF1R (0.82) | IGF1RTNK2CYP2C9 | |
| SCHEMBL400047 | 0.74 | IGF1R (0.68) | IGF1RTNK2CYP2C9 | |
| SCHEMBL399407 | 0.71 | IGF1R (0.59) | IGF1RTNK2 | |
| SCHEMBL401246 | 0.71 | IGF1R (0.77) | IGF1RTNK2 | |
| SCHEMBL402488 | 0.70 | IGF1R (0.55) | IGF1RTNK2 | |
| SCHEMBL5148560 | 0.68 | TNK2 (0.51) | IGF1RTNK2 | |
| SCHEMBL5312424 | 0.68 | IGF1R (0.47) | IGF1RTNK2CYP2C9 | |
| SCHEMBL402468 | 0.68 | TNK2 (0.75) | IGF1RTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |