Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400047 | 0.83 | IGF1R (0.68) | IGF1RTNK2CYP2C9 | |
| SCHEMBL5080691 | 0.75 | IGF1R (0.36) | IGF1RTNK2CYP2C9 | |
| SCHEMBL402609 | 0.72 | IGF1R (0.82) | IGF1RTNK2CYP2C9 | |
| SCHEMBL402602 | 0.72 | IGF1R (0.63) | IGF1RTNK2CYP2C9 | |
| SCHEMBL5313007 | 0.71 | IGF1R (0.45) | IGF1RTNK2BTK | |
| SCHEMBL5175019 | 0.68 | IGF1R (0.52) | IGF1RTNK2CYP2C9 | |
| SCHEMBL398801 | 0.68 | IGF1R (0.62) | IGF1RTNK2CYP2C9 | |
| SCHEMBL402468 | 0.65 | TNK2 (0.75) | IGF1RTNK2 | |
| SCHEMBL397510 | 0.65 | TNK2 (0.64) | IGF1RTNK2 | |
| SCHEMBL397857 | 0.65 | SRC (0.56) | IGF1RCYP2C9BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |