Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Albuterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 10/20 | 0.82 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.86 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Albuterol SCHEMBL5472399 | 0.97 | PMP22 (0.86) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL29372778 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Levosalbutamol SCHEMBL29568212 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL28342432 | 0.92 | PMP22 (0.95) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL3635442 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL33279 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Levosalbutamol SCHEMBL33281 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL2556890 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL6861017 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 | |
| Albuterol SCHEMBL2405201 | 0.92 | PMP22 (1.00) | PMP22ADRB2ADRB1HIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449161-B2 | Pharmaceutical compositions for inhalation | VECTURA LIMITED (GB) | 2019-10-22 | — | — | US | disclosed |
| US-10188612-B2 | Pharmaceutical compositions for inhalation | VECTURA LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| US-9962338-B2 | Method of making particles for use in a pharmaceutical composition | VECTURA LIMITED (GB) | 2018-05-08 | — | — | US | disclosed |
| US-20170172947-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHALATION | VECTURA LTD (GB) | 2017-06-22 | — | — | US | disclosed |
| US-9585839-B2 | Particles for use in a pharmaceutical composition | VECTURA LIMITED (GB) | 2017-03-07 | — | — | US | disclosed |
| US-20160243046-A1 | METHOD OF MAKING PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2016-08-25 | — | — | US | disclosed |
| US-20150086640-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHALATION | VECTURA LTD (GB) | 2015-03-26 | — | — | US | disclosed |
| US-8956661-B2 | Method of making composite particles for use in pharmaceutical compositions and composite particles and compositions thereof | VECTURA LIMITED (GB) | 2015-02-17 | — | — | US | disclosed |
| US-8932635-B2 | Pharmaceutical compositions of hydrophobic surface-modified active substance microparticles for inhalation | VECTURA LIMITED (GB) | 2015-01-13 | — | — | US | disclosed |
| EP-1337240-B2 | METHOD OF MAKING PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| US-20130017267-A1 | METHOD OF MAKING PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LIMITED (GB) | 2013-01-17 | — | — | US | disclosed |
| US-8303991-B2 | Method of making particles for use in a pharmaceutical composition | VECTURA LIMITED (GB) | 2012-11-06 | — | — | US | disclosed |
| US-20120027863-A1 | Pharmaceutical Compositions for Inhalation | VECTURA LIMITED (GB) | 2012-02-02 | — | — | US | disclosed |
| US-8048451-B2 | Pharmaceutical compositions for inhalation | VECTURA LIMITED (GB) | 2011-11-01 | — | — | US | disclosed |
| EP-1337240-B1 | METHOD OF MAKING PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION | VECTURA LTD (GB) | 2011-07-27 | — | — | EP | disclosed |
| EP-2292212-A2 | Method of making particles for use in a pharmaceutical composition | Vectura Limited (GB) | 2011-03-09 | — | — | EP | disclosed |
| EP-2283817-A1 | Method of making particles for use in a pharmaceutical composition | Vectura Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| EP-2283818-A1 | Method of making particles for use in a pharmaceutical composition | Vectura Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| US-20100209358-A1 | Method of Making Particles For Use In A Pharmaceutical Composition | VECTURA LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| US-7736670-B2 | The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the | VECTURA LIMITED (GB) | 2010-06-15 | — | — | US | disclosed |