Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25969813 | 0.97 | ATM (0.45) | KDM1AATMLMNACYP1A2CYP2D6 | |
| SCHEMBL6012057 | 0.91 | ATM (0.44) | KDM1AATMLMNACYP1A2CYP2D6 | |
| SCHEMBL25969912 | 0.85 | CYP2D6 (0.54) | KDM1ALMNACYP1A2CYP2D6HIF1A | |
| SCHEMBL25969915 | 0.85 | CYP2D6 (0.54) | KDM1ALMNACYP1A2CYP2D6HIF1A | |
| SCHEMBL6536075 | 0.85 | CYP2D6 (0.54) | KDM1ALMNACYP1A2CYP2D6HIF1A | |
| SCHEMBL20595718 | 0.85 | CYP2D6 (0.54) | KDM1ALMNACYP1A2CYP2D6HIF1A | |
| SCHEMBL862012 | 0.84 | KDM1A (0.45) | KDM1AATMFKBP1AOPRD1PRMT5 | |
| SCHEMBL5174287 | 0.83 | PARP1 (0.45) | LMNASLC6A4SLC6A3SLC6A2PRMT5 | |
| SCHEMBL10541561 | 0.82 | UCHL1 (0.46) | KDM1AATMOPRD1PRMT5CHEK2 | |
| SCHEMBL842715 | 0.81 | KDM1A (0.42) | KDM1AATMLMNAFKBP1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |