Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 15/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178049 | 0.92 | CHEK2 (0.67) | CHEK2ALDH1A1 | |
| SCHEMBL5177628 | 0.91 | CHEK2 (0.72) | CHEK2ALDH1A1 | |
| SCHEMBL5177810 | 0.91 | CHEK2 (0.67) | CHEK2ALDH1A1 | |
| SCHEMBL5178080 | 0.91 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL5177744 | 0.90 | CHEK2 (0.69) | CHEK2ALDH1A1 | |
| SCHEMBL5178184 | 0.87 | CHEK2 (0.68) | CHEK2 | |
| SCHEMBL5178402 | 0.87 | CHEK2 (0.51) | CHEK2ALDH1A1PRMT1 | |
| SCHEMBL5176583 | 0.87 | CHEK2 (0.68) | CHEK2 | |
| SCHEMBL5177233 | 0.85 | CHEK2 (0.68) | CHEK2ALDH1A1 | |
| SCHEMBL1379810 | 0.85 | CHEK2 (0.85) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-B1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5]-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-06 | — | — | EP | claimed |