⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28754513 | 1.00 | — | — | |
| SCHEMBL300957 | 1.00 | — | — | |
| Water SCHEMBL7973820 | 0.96 | — | — | |
| SCHEMBL3825991 | 0.80 | — | — | |
| SCHEMBL7952012 | 0.76 | — | — | |
| SCHEMBL13534419 | 0.75 | — | — | |
| SCHEMBL996739 | 0.72 | — | — | |
| SCHEMBL9528614 | 0.72 | — | — | |
| SCHEMBL11768466 | 0.70 | — | — | |
| Isobutyraldehyde SCHEMBL2635854 | 0.70 | ADH1B (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100439392-C | Novel method for the synthesis of perinidopril and the pharmaceutically acceptable salts thereof | SERVIER LAB (FR) | 2008-12-03 | — | — | CN | disclosed |
| EP-1420028-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2007-02-21 | — | — | EP | disclosed |
| EP-1367062-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2006-08-30 | — | — | EP | disclosed |
| CN-1826351-A | Novel method for the synthesis of perinidopril and the pharmaceutically acceptable salts thereof | SERVIER LAB (FR) | 2006-08-30 | — | — | CN | disclosed |
| EP-1367063-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005054276-A1 | METHOD FOR SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005012328-A2 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012333-A2 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-02-10 | — | — | WO | disclosed |
| EP-1420028-A2 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATOIRES SERVIER (FR) | 2004-05-19 | — | — | EP | disclosed |
| EP-1367062-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | Les Laboratoires Servier (FR) | 2003-12-03 | — | — | EP | disclosed |
| EP-1367063-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | Les Laboratoires Servier (FR) | 2003-12-03 | — | — | EP | disclosed |