Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473465 | 0.86 | MAPT (0.47) | MAPTMAPK1KMT2ABLMMEN1 | |
| SCHEMBL4475566 | 0.83 | MAPT (0.60) | MAPTMAPK1KMT2ABLML3MBTL1 | |
| SCHEMBL5177886 | 0.82 | KMT2A (0.44) | MAPTMAPK1KMT2ABLMMEN1 | |
| SCHEMBL4469214 | 0.77 | KMT2A (0.46) | MAPTMAPK1KMT2AMEN1POLB | |
| SCHEMBL4489964 | 0.77 | MAPT (0.49) | MAPTMAPK1KMT2ABLML3MBTL1 | |
| SCHEMBL3812555 | 0.77 | MAPT (0.49) | MAPTMAPK1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL3813835 | 0.75 | PKM (0.55) | MAPTMAPK1BLMGSK3AGSK3B | |
| SCHEMBL3812850 | 0.75 | PRKCQ (0.55) | MAPTMAPK1KMT2AMEN1GSK3A | |
| SCHEMBL3819566 | 0.75 | MAPT (0.47) | MAPTMAPK1KMT2AMEN1L3MBTL1 | |
| SCHEMBL3813101 | 0.75 | MAPT (0.47) | MAPTMAPK1KMT2ABLMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765791-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006014482-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |