SCHEMBL5178141

SCHEMBL5178141

COC(=O)N[Si](OC)(OC)OC

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.36
ALDH1A1 P00352 1/20 0.35
HSD17B10 Q99714 1/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30
HCAR2 Q8TDS4 1/20 0.30
LMNA P02545 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
EPHX1 P07099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17137897 0.78 GAA (0.48) TSHRALDH1A1HSD17B10MGAMGAA
SCHEMBL27677780 0.77 ALDH1A1 (0.42) TSHRALDH1A1HSD17B10MGAMGAA
SCHEMBL4604083 0.77 TSHR (0.36) TSHRALDH1A1HSD17B10MGAMGAA
SCHEMBL20544699 0.76 TSHR (0.33) TSHRHSD17B10MGAMGAASI
SCHEMBL5177247 0.74 ALDH1A1 (0.33) ALDH1A1NPSR1
SCHEMBL5789591 0.74 TSHR (0.35) TSHRALDH1A1HSD17B10MGAMGAA
SCHEMBL23926413 0.74 KDM4E (0.40) ALDH1A1HCAR2SMN1; SMN2EPHX1
SCHEMBL1950611 0.73
SCHEMBL14941367 0.70 TSHR (0.38) TSHRALDH1A1HSD17B10MGAMGAA
SCHEMBL21372375 0.69 TSHR (0.39) TSHRALDH1A1KEAP1NFE2L2HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103694946-B Method for producing silane modified polyurethane sealant by using secondary amino alpha-silane HUBEI BLUESKY NEW MATERIALS INC 2015-06-17 CN claimed
CN-102449033-B Curable compositions containing silyl groups, and use thereof EVONIK GOLDSCHMIDT GMBH 2014-05-07 CN claimed
CN-102449033-A Curable compositions comprising silyl groups and uses thereof EVONIK GOLDSCHMIDT GMBH 2012-05-09 CN claimed
CN-114008164-B Moisture curable composition and method for preparing moisture curable composition 瓦克化学股份公司 2023-08-11 CN disclosed
CN-103694946-B Method for producing silane modified polyurethane sealant by using secondary amino alpha-silane HUBEI BLUESKY NEW MATERIALS INC 2015-06-17 CN disclosed
CN-101273074-B Preparation of amino-silane terminated polymer by using organic bismuth catalyst and cured polymer therefrom by using non-tin catalyst MOMENTIVE PERFORMANCE MAT INC 2013-06-26 CN disclosed
CN-101273074-A Preparation of amino-silane terminated polymer by using organic bismuth catalyst and cured polymer therefrom by using non-tin catalyst MOMENTIVE PERFORMANCE MAT INC (US) 2008-09-24 CN disclosed
US-20070255005-A1 Process for Producing Curable Resin Composition KANEKA BELGIUM N.V. (BE) 2007-11-01 US disclosed
EP-1535940-B1 Process for the preparation of organyloxysilylterminated polymers WACKER CHEMIE AG (DE) 2007-06-13 EP disclosed
EP-1767584-A1 PROCESS FOR PRODUCING CURABLE RESIN COMPOSITION Kaneka Corporation (JP) 2007-03-28 EP disclosed
EP-1535940-A1 Process for the preparation of organyloxysilylterminated polymers Wacker-Chemie GmbH (DE) 2005-06-01 EP disclosed