Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.49 |
| ▸ | CA2 | P00918 | 16/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748579 | 0.85 | CA1 (0.45) | CA1CA2CA9CA12 | |
| SCHEMBL1279094 | 0.83 | ALDH1A1 (0.53) | CA1CA2CA9 | |
| SCHEMBL29350373 | 0.83 | ALDH1A1 (0.53) | CA1CA2CA9 | |
| SCHEMBL6118940 | 0.82 | CA1 (0.69) | CA1CA2CA9CA12CA6 | |
| SCHEMBL7297478 | 0.82 | CA1 (0.50) | CA1CA2GAAKDM4ECA9 | |
| SCHEMBL7133530 | 0.82 | CA1 (0.40) | CA1CA2KDM4E | |
| SCHEMBL2575446 | 0.81 | CA1 (0.49) | CA1CA2GAAKDM4ECA9 | |
| SCHEMBL30752023 | 0.81 | CA1 (0.49) | CA1CA2GAAKDM4ECA9 | |
| SCHEMBL27502345 | 0.81 | CA1 (0.49) | CA1CA2GAAKDM4ECA9 | |
| SCHEMBL5968076 | 0.80 | ALDH1A1 (0.63) | CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794150-A1 | Benzimidazole derivatives and their use as cannabinoid receptor ligands I | AstraZeneca AB (SE) | 2007-06-13 | — | — | EP | disclosed |
| EP-1670770-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2006033632-A1 | Benzimidazole derivatives and their use as cannabinoid receptor ligands I | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005030733-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |