SCHEMBL5178247

SCHEMBL5178247

CC(=O)C(C)Cc1c(C)nc2ccc(Br)cc2c1-c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.62
RXFP1 Q9HBX9 3/20 0.60
PRNP P04156 1/20 0.60
PPARG P37231 1/20 0.60
NR2E3 Q9Y5X4 1/20 0.60
NCOR2 Q9Y618 1/20 0.60
DPP4 P27487 2/20 0.55
KDM4E B2RXH2 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.48
HTT P42858 1/20 0.45
CASP3 P42574 5/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
FABP3 P05413 1/20 0.43
FABP4 P15090 1/20 0.43
CYP3A4 P08684 1/20 0.43
PTGFR P43088 1/20 0.43
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5178272 0.77 RXFP1 (0.60) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL2822472 0.77 ALDH1A1 (1.00) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL27684995 0.76 RXFP1 (0.65) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL2825415 0.76 PRNP (0.72) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL3903825 0.75 DPP4 (0.69) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL2822202 0.74 ALDH1A1 (0.67) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL2821515 0.73 RXFP1 (0.81) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL2821491 0.73 RXFP1 (0.75) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL3895184 0.73 DPP4 (0.78) ALDH1A1RXFP1PRNPPPARGNR2E3
SCHEMBL5178617 0.72 ALDH1A1 (0.55) ALDH1A1RXFP1PRNPPPARGNR2E3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1809605-A1 QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS F. Hoffmann-Roche AG (CH) 2007-07-25 EP claimed
WO-2006048146-A1 QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2006-05-11 WO claimed
EP-1809605-A1 QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS F. Hoffmann-Roche AG (CH) 2007-07-25 EP disclosed
WO-2006048146-A1 QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2006-05-11 WO disclosed