Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27533184 | 0.81 | TSHR (0.52) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL2128784 | 0.81 | TSHR (0.52) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL2001980 | 0.81 | TSHR (0.52) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL51153 | 0.81 | TSHR (0.52) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| Hydrochloric Acid SCHEMBL27474797 | 0.79 | TSHR (0.50) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL15021274 | 0.79 | TSHR (0.50) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL28006880 | 0.79 | TSHR (0.50) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL11444625 | 0.79 | TSHR (0.50) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL11444701 | 0.79 | TSHR (0.50) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL10701795 | 0.78 | TDP1 (0.47) | TSHRALDH1A1SLC6A3TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856747-B1 | SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN LA ROCHE (CH) | 2023-07-19 | — | — | EP | claimed |
| EP-3856747-A1 | SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-08-04 | — | — | EP | claimed |
| US-20210221832-A1 | SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2021-07-22 | — | — | US | claimed |
| WO-2020064661-A1 | SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-02 | — | — | WO | claimed |
| EP-0335297-B1 | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-13 | — | — | EP | claimed |
| US-5336768-A | Bactericides | HOFFMANN-LA ROCHE INC. (US) | 1994-08-09 | — | — | US | claimed |
| US-5329002-A | Piperazinium protected carboxylic acid antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1994-07-12 | — | — | US | claimed |
| EP-0251330-B1 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | HOFFMANN LA ROCHE (CH) | 1993-12-01 | — | — | EP | claimed |
| US-5189157-A | ANTIBACTERIAL CEPHALOSPORIN COMPOUNDS | HOFFMANN LA ROCHE INC. (US) | 1993-02-23 | — | — | US | claimed |
| EP-0243924-B1 | 2-OXO-1-(SUBSTITUTED PHOSPHOROUS)AZETIDINES | E.R. Squibb & Sons, Inc. (US) | 1992-12-23 | — | — | EP | claimed |
| EP-0295630-A2 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-12-21 | — | — | EP | claimed |
| US-4775670-A | BACTERICIDES, ANTIBIOTICS | E. R. SQUIBB & SONS, INC. (US) | 1988-10-04 | — | — | US | claimed |
| EP-0048953-B1 | BETA-LACTAM ANTIBIOTICS | E.R. Squibb & Sons, Inc. (US) | 1988-03-09 | — | — | EP | claimed |
| EP-0251330-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-01-07 | — | — | EP | claimed |
| EP-0206000-A1 | (2,3)-Alpha-methylenepenam-3-carboxylic acids and derivatives thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1986-12-30 | — | — | EP | claimed |
| EP-0187355-A1 | Process for preparing beta-lactam antibiotics | E.R. Squibb & Sons, Inc. (US) | 1986-07-16 | — | — | EP | claimed |
| US-4533660-A | Antibacterial O-sulfated β-lactam hydroxamic acids | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | claimed |
| EP-0051381-B1 | O-SULFATED BETA-LACTAM HYDROXAMIC ACIDS | E.R. Squibb & Sons, Inc. (US) | 1985-01-30 | — | — | EP | claimed |
| EP-0051381-A1 | O-sulfated beta-lactam hydroxamic acids | E.R. Squibb & Sons, Inc. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0048953-A2 | Beta-lactam antibiotics | E.R. Squibb & Sons, Inc. (US) | 1982-04-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221832-A1 | SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | BLVRB, PNPO, IL17A | TSHR 1984/4885ALDH1A1 1121/4885SLC6A2 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.