Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 5/20 | 0.40 |
| ▸ | PTGFR | P43088 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178029 | 0.90 | DHODH (0.48) | KDM4ESMN1; SMN2PLA2G2ALMNADHODH | |
| SCHEMBL5177281 | 0.90 | KDM4E (0.47) | KDM4ESMN1; SMN2PTGFRPLA2G2ALMNA | |
| SCHEMBL5178422 | 0.86 | DHODH (0.40) | KDM4EDHODH | |
| SCHEMBL5177389 | 0.81 | KDM4E (0.52) | KDM4ESMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL27685115 | 0.80 | PTGFR (0.40) | KDM4ESMN1; SMN2PTGFRARPLA2G2A | |
| SCHEMBL27704155 | 0.79 | PTGFR (0.40) | KDM4ESMN1; SMN2PTGFRARPLA2G2A | |
| SCHEMBL5178272 | 0.79 | RXFP1 (0.60) | KDM4ESMN1; SMN2DPP4PTGFRMEN1 | |
| SCHEMBL3350429 | 0.79 | KDM4E (0.70) | KDM4ESMN1; SMN2PLA2G2ALMNADHODH | |
| SCHEMBL2822038 | 0.79 | FABP3 (0.51) | KDM4ESMN1; SMN2PTGFRPLA2G2AMEN1 | |
| SCHEMBL28661629 | 0.78 | SMN1; SMN2 (0.65) | KDM4ESMN1; SMN2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | claimed |
| WO-2006048146-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | claimed |
| EP-1809605-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048146-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |