Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | FABP4 | P15090 | 5/20 | 0.60 |
| ▸ | FABP3 | P05413 | 4/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177389 | 0.87 | KDM4E (0.52) | KDM4EFABP4FABP3SMN1; SMN2LMNA | |
| SCHEMBL5177676 | 0.86 | SMN1; SMN2 (0.54) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 | |
| SCHEMBL5178272 | 0.85 | RXFP1 (0.60) | KDM4EFABP4FABP3SMN1; SMN2HTT | |
| SCHEMBL28661629 | 0.84 | SMN1; SMN2 (0.65) | KDM4ESMN1; SMN2LMNAMAPK1MAPT | |
| SCHEMBL31442473 | 0.82 | KDM4E (0.49) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 | |
| SCHEMBL3346066 | 0.81 | KDM4E (0.71) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 | |
| SCHEMBL5178406 | 0.79 | KDM4E (0.47) | KDM4EPLA2G2ASMN1; SMN2LMNADHODH | |
| SCHEMBL5178029 | 0.79 | DHODH (0.48) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 | |
| SCHEMBL5177281 | 0.79 | KDM4E (0.47) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 | |
| SCHEMBL27703988 | 0.76 | FABP4 (0.58) | KDM4EFABP4FABP3PLA2G2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | claimed |
| WO-2006048146-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | claimed |
| WO-2010056865-A1 | QUINOLINE DERIVATIVES AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| EP-1809605-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048146-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |