Toluene

Toluene

SCHEMBL5178478

CCN(CC)CC.CCOC(C)=O.CO.Cc1ccccc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
LMNA P02545 3/20 0.48
HSD17B10 Q99714 1/20 0.48
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
CYP3A4 P08684 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CHRM2 P08172 2/20 0.41
CHRM1 P11229 2/20 0.41
CHRM3 P20309 2/20 0.41
CHRM4 P08173 1/20 0.41
CHRM5 P08912 1/20 0.41
POLB P06746 2/20 0.40
PIN1 Q13526 1/20 0.40
GAA P10253 1/20 0.40
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL2960642 0.98 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10CYP1A2CYP2D6
Toluene SCHEMBL1609296 0.91 ALDH1A1 (0.58) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL27492562 0.89 ALDH1A1 (0.56) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL27491226 0.89 ALDH1A1 (0.56) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL10467735 0.89 ALDH1A1 (0.56) ALDH1A1LMNAHSD17B10TSHRMEN1
Ethyl Acetate SCHEMBL9198477 0.89 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10CYP1A2CYP2D6
Toluene SCHEMBL6453722 0.89 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL15348475 0.89 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL8533815 0.89 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRMEN1
Toluene SCHEMBL9305273 0.89 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100493589-C Herbal preparation for arthritis HONG KONG JOCKEY CLUB INST OF (HK) 2009-06-03 CN disclosed
EP-1019358-B2 3,3-DIARYLPROPYLAMINES , THEIR USE AND PREPARATION PFIZER HEALTH AB (SE) 2007-09-12 EP disclosed
CN-1778383-A Herbal preparation for arthritis HONG KONG JOCKEY CLUB INST OF (HK) 2006-05-31 CN disclosed
EP-1019358-B1 3,3-DIARYLPROPYLAMINES , THEIR USE AND PREPARATION PHARMACIA AB (SE) 2003-05-07 EP disclosed
US-6313132-B1 FOR THERAPY OF URINARY INCONTINENCE, ACETYLCHOLINE-MEDIATED DISORDER PHARMACIA AB (SE) 2001-11-06 US disclosed
EP-1019358-A1 NOVEL COMPOUNDS, THEIR USE AND PREPARATION Pharmacia & Upjohn AB (SE) 2000-07-19 EP disclosed
WO-1998043942-A1 NOVEL COMPOUNDS, THEIR USE AND PREPARATION PHARMACIA & UPJOHN AB (SE) 1998-10-08 WO disclosed
US-5476931-A Reacting with a base in a mixed solvent containing alcohol RIKAGAKU KENKYUSHO (JP) 1995-12-19 US disclosed
EP-0311694-B1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION RIKAGAKU KENKYUSHO (JP) 1995-12-13 EP disclosed
US-5144018-A Antiviral Agents RIKAGAKU KENKYUSHO (JP) 1992-09-01 US disclosed
EP-0311694-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION RIKAGAKU KENKYUSHO (JP) 1989-04-19 EP disclosed