Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.65 |
| ▸ | RXRB | P28702 | 15/20 | 0.65 |
| ▸ | RXRG | P48443 | 15/20 | 0.65 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 4/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.41 |
| ▸ | RARG | P13631 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179730 | 0.88 | RXRA (0.83) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5179745 | 0.87 | RXRA (0.61) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5180347 | 0.86 | RXRA (0.59) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5179743 | 0.84 | RXRA (0.64) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL17049060 | 0.83 | RXRA (0.78) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL17049097 | 0.79 | RXRA (1.00) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5179721 | 0.74 | RXRA (0.58) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5180019 | 0.73 | RXRA (0.76) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5180413 | 0.73 | RXRA (0.44) | RXRARXRBRXRGPPARGRARA | |
| SCHEMBL5179608 | 0.73 | RXRA (0.76) | RXRARXRBRXRGPPARGNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180520-B1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES | INST MED MOLECULAR DESIGN INC (JP) | 2007-06-20 | — | — | EP | disclosed |
| US-6869959-B1 | Heterocyclic carboxylic acid derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN INC. (JP) | 2005-03-22 | — | — | US | disclosed |
| EP-1180520-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES | Institute of Medicinal Molecular Design, Inc. (JP) | 2002-02-20 | — | — | EP | disclosed |