Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344607 | 0.82 | P2RX7 (0.56) | P2RX7LMNARAB9ASMN1; SMN2MAPK14 | |
| SCHEMBL30557747 | 0.81 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL3476055 | 0.81 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL3472355 | 0.81 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL3473601 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL13433834 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| Ce-224535 SCHEMBL3473047 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL13433833 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3475207 | 0.81 | P2RX7 (1.00) | P2RX7 | |
| Ce-224535 SCHEMBL3475321 | 0.81 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768965-A1 | METHOD FOR PREPARING 5-¬4-(2-HYDROXY-ETHYL)-3,5-DIOXO-4,5-DIHYDRO-3H-¬1,2,4|-TRIAZIN-2-YL|BENZAMIDE DERIVATIVES WITH P2X7 INHIBITING ACTIVITY BY REACTION OF THE DERIVATIVE UNSUBSTITUTED IN 4-POSITION OF THE TRIAZINE WITH AN OXIRAN IN THE PRESENCE OF A LEWIS ACID | Pfizer Products Incorporated (US) | 2007-04-04 | — | — | EP | claimed |
| WO-2006003513-A1 | METHOD FOR PREPARING 5-`4-(2-HYDROXY-ETHYL)-3,5-DIOXO-4,5-DIHYDRO-3H-`1,2,4!-TRIAZIN-2-YL!BENZAMIDE DERIVATIVES WITH P2X7 INHIBITING ACTIVITY BY REACTION OF THE DERIVATIVE UNSUBSTITUTED IN 4-POSITION OF THE TRIAZINE WITH AN OXIRAN IN THE PRESENCE OF A LEWIS ACID | PFIZER PRODUCTS INC. (US) | 2006-01-12 | — | — | WO | claimed |