Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9617060 | 0.91 | TDP1 (0.33) | POLBAPEX1TDP1 | |
| SCHEMBL7346799 | 0.90 | — | — | |
| SCHEMBL7351338 | 0.90 | — | — | |
| SCHEMBL107504 | 0.90 | — | — | |
| Trifluoroacetic Acid SCHEMBL31745104 | 0.86 | — | — | |
| Cyclohexene SCHEMBL8175251 | 0.85 | — | — | |
| Methacrylic Acid SCHEMBL10649993 | 0.84 | — | — | |
| Phosphoric Acid SCHEMBL27454959 | 0.84 | — | — | |
| SCHEMBL1071594 | 0.82 | — | — | |
| SCHEMBL14612282 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1589031-B1 | Production of polyketides and other natural products | BIOTICA TECH LTD (GB) | 2007-08-15 | — | — | EP | claimed |