Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 10/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5180351 | 0.89 | MAPT (0.73) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5180345 | 0.89 | MAPT (0.73) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5180278 | 0.85 | MAPT (0.60) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5180284 | 0.85 | MAPT (0.60) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5179613 | 0.70 | LMNA (0.60) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5179611 | 0.70 | LMNA (0.60) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5181450 | 0.68 | MAPT (0.64) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5182238 | 0.68 | MAPT (0.64) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5181626 | 0.68 | MEN1 (0.74) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5181623 | 0.68 | MEN1 (0.74) | MAPTSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399159-A4 | 4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2007-02-14 | — | — | EP | claimed |
| EP-1399159-A1 | 4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2004-03-24 | — | — | EP | claimed |
| WO-2002098420-A1 | 4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-12-12 | — | — | WO | claimed |