Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.51 |
| ▸ | MTOR | P42345 | 8/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934405 | 0.84 | PIK3CA (0.58) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL30599038 | 0.82 | MTOR (0.48) | PIK3CAMTORPIK3CGPIK3CDRAF1 | |
| SCHEMBL4936100 | 0.82 | MTOR (0.48) | PIK3CAMTORPIK3CGPIK3CDRAF1 | |
| SCHEMBL5183870 | 0.79 | PIK3CA (0.54) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL4937769 | 0.79 | MTOR (0.45) | PIK3CAMTORMAPTPIK3CGRAF1 | |
| SCHEMBL4935122 | 0.78 | PIK3CA (0.59) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL4941085 | 0.78 | PIK3CA (0.61) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL4605078 | 0.77 | PIK3CA (0.53) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL4938348 | 0.75 | PIK3CA (0.63) | PIK3CAMTORNPSR1MAPTTSHR | |
| SCHEMBL5217589 | 0.74 | PIK3CA (0.49) | PIK3CAMTORNPSR1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778681-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006005918-A1 | 2, 4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2006-01-19 | — | — | WO | disclosed |