Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.47 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183564 | 1.00 | TRPA1 (0.53) | TRPA1PTPN1NFE2L2SLC5A1SLC5A2 | |
| SCHEMBL31414593 | 0.87 | PTPN1 (0.68) | TRPA1PTPN1NFE2L2KDM4EMEN1 | |
| SCHEMBL31414592 | 0.87 | PTPN1 (0.68) | TRPA1PTPN1NFE2L2KDM4EMEN1 | |
| SCHEMBL27677458 | 0.81 | PTPN1 (0.76) | TRPA1PTPN1NFE2L2SLC5A1SLC5A2 | |
| SCHEMBL11289265 | 0.79 | PTPN1 (0.60) | TRPA1PTPN1NFE2L2SLC5A1SLC5A2 | |
| SCHEMBL2720853 | 0.79 | TRPA1 (0.53) | TRPA1PTPN1SLC5A1SLC5A2KDM4E | |
| SCHEMBL2720849 | 0.79 | TRPA1 (0.53) | TRPA1PTPN1SLC5A1SLC5A2KDM4E | |
| SCHEMBL6229519 | 0.76 | SLC5A1 (0.61) | TRPA1PTPN1SLC5A1SLC5A2KDM4E | |
| SCHEMBL6229522 | 0.76 | SLC5A1 (0.61) | TRPA1PTPN1SLC5A1SLC5A2KDM4E | |
| SCHEMBL30358577 | 0.76 | SLC5A1 (0.61) | TRPA1PTPN1SLC5A1SLC5A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753708-A4 | NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME | UNIV BRIGHAM YOUNG (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1753708-A2 | NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME | Brigham Young University (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005069998-A2 | NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME | BRIGHAM YOUNG UNIVERSITY TECHNOLOGY TRANSFER OFFICE (US) | 2005-08-04 | — | — | WO | disclosed |