Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949387 | 0.97 | ALDH1A1 (0.73) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL27881214 | 0.90 | TSHR (0.70) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL11427520 | 0.89 | TSHR (0.73) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL1073658 | 0.89 | ALDH1A1 (0.71) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL9969538 | 0.89 | TSHR (0.65) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL11329001 | 0.88 | TSHR (0.73) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| Ammonia Solution, Strong SCHEMBL28026710 | 0.87 | TSHR (0.62) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL11421173 | 0.86 | ALDH1A1 (0.65) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL11330763 | 0.86 | ALDH1A1 (0.74) | ALDH1A1ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL975212 | 0.85 | TSHR (0.77) | ALDH1A1ADRB2ADRB1ADRB3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799747-A1 | METHOD FOR INCORPORATING ALKYL ESTER ENDGROUPS TO IMPROVE THE RELEASE PROPERTIES OF MELT POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2007-06-27 | — | — | EP | claimed |
| US-7105626-B2 | Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate | GENERAL ELECTRIC COMPANY (US) | 2006-09-12 | — | — | US | claimed |
| US-20060074216-A1 | Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2006-04-06 | — | — | US | claimed |
| WO-2006031668-A1 | METHOD FOR INCORPORATING ALKYL ESTER ENDGROUPS TO IMPROVE THE RELEASE PROPERTIES OF MELT POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2006-03-23 | — | — | WO | claimed |