SCHEMBL5185690

CC(=O)Cc1cccc(-c2ccc3c(c2)CC(N(C(C(C)S(=O)(=O)NC2Cc4ccc(-c5cccc(CNS(C)(=O)=O)c5)cc4C2)(N(C2Cc4ccc(-c5cccc(C#N)c5)cc4C2)S(=O)(=O)C(C)C)N(C2Cc4ccc(-c5cccc(CN)c5)cc4C2)S(=O)(=O)C(C)C)S(=O)(=O)C(C)C)C3)c1

nearest known ligand 0.53

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	GRIA2	P42262	16/20	0.53

▸	CYP1A2	P05177	1/20	0.34

▸	NR1H2	P55055	2/20	0.33

▸	CYP2C19	P33261	1/20	0.31

▸	MCHR1	Q99705	1/20	0.31

▸	HRH3	Q9Y5N1	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5185695	0.89	GRIA2 (0.68)	GRIA2CYP1A2CYP2C19
SCHEMBL5197494	0.76	GRIA2 (0.64)	GRIA2CYP1A2CYP2C19
SCHEMBL5197490	0.76	GRIA2 (0.50)	GRIA2CYP1A2CYP2C19
SCHEMBL2932604	0.72	GRIA2 (1.00)	GRIA2CYP1A2CYP2C19
SCHEMBL2928683	0.72	GRIA2 (0.70)	GRIA2CYP1A2CYP2C19
SCHEMBL2930121	0.69	GRIA2 (0.74)	GRIA2CYP1A2CYP2C19
SCHEMBL2930332	0.69	GRIA2 (0.74)	GRIA2CYP1A2CYP2C19
SCHEMBL2934389	0.66	GRIA2 (0.77)	GRIA2CYP1A2CYP2C19
SCHEMBL13297274	0.63	BRD4 (0.50)	GRIA2
SCHEMBL2934808	0.62	GRIA2 (0.73)	GRIA2CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1786766-A1	COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE	GLAXO GROUP LIMITED (GB)	2007-05-23	—	—	EP	disclosed
WO-2006015829-A1	COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE	GLAXO GROUP LIMITED (GB)	2006-02-16	—	—	WO	disclosed