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SCHEMBL5197490

SCHEMBL5197490

CC(CN(C1Cc2ccc(-c3cccc(CN)c3)cc2C1)S(=O)(=O)C(C)C)S(=O)(=O)NC1Cc2ccc(-c3cccc(CNS(C)(=O)=O)c3)cc2C1

nearest known ligand 0.50

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ GRIA2 P42262 20/20 0.50
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5197494 0.87 GRIA2 (0.64) GRIA2CYP1A2CYP2C19
SCHEMBL2928683 0.82 GRIA2 (0.70) GRIA2CYP1A2CYP2C19
SCHEMBL2930121 0.79 GRIA2 (0.74) GRIA2CYP1A2CYP2C19
SCHEMBL5185690 0.76 GRIA2 (0.53) GRIA2CYP1A2CYP2C19
SCHEMBL5185695 0.76 GRIA2 (0.68) GRIA2CYP1A2CYP2C19
SCHEMBL5185097 0.74 GRIA2 (0.64) GRIA2CYP1A2CYP2C19
SCHEMBL2934808 0.73 GRIA2 (0.73) GRIA2CYP1A2CYP2C19
SCHEMBL3350020 0.72 GRIA2 (0.46) GRIA2CYP1A2CYP2C19
SCHEMBL13297274 0.72 BRD4 (0.50) GRIA2
SCHEMBL2934389 0.70 GRIA2 (0.77) GRIA2CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786766-A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-05-23 — — EP claimed
WO-2006015829-A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2006-02-16 — — WO claimed