⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187818 | 0.91 | TSHR (0.43) | — | |
| SCHEMBL620969 | 0.90 | — | — | |
| SCHEMBL873013 | 0.90 | TSHR (0.42) | — | |
| SCHEMBL8089816 | 0.88 | TSHR (0.41) | — | |
| SCHEMBL8098922 | 0.88 | TSHR (0.41) | — | |
| SCHEMBL106091 | 0.88 | TSHR (0.41) | — | |
| SCHEMBL1035256 | 0.86 | TSHR (0.43) | — | |
| SCHEMBL25223710 | 0.84 | TSHR (0.46) | — | |
| Hydrochloric Acid SCHEMBL23037273 | 0.84 | TSHR (0.42) | — | |
| SCHEMBL3264014 | 0.84 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043625-B2 | Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-07-23 | — | — | US | disclosed |
| US-12043625-B2 | Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-07-23 | — | — | US | disclosed |
| EP-4337327-A1 | PYRIDINE DERIVATIVES WITH C-LINKED CYCLIC SUBSTITUENTS AS CGAS INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-03-20 | — | — | EP | disclosed |
| CN-117677614-A | Heterocyclic compound with AKT kinase inhibition activity, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117337291-A | Pyridine derivatives having C-linked cyclic substituents as cGAS inhibitors | 勃林格殷格翰国际有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-116514817-A | Heterocyclic compound with AKT kinase inhibition activity, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-08-01 | — | — | CN | disclosed |
| WO-2023109540-A1 | HETEROCYCLIC COMPOUND WITH AKT KINASE INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2023-06-22 | — | — | WO | disclosed |
| US-20230002401-A1 | PYRIDINE DERIVATIVES WITH C-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-01-05 | — | — | US | disclosed |
| WO-2022238335-A1 | PYRIDINE DERIVATIVES WITH C-LINKED CYCLIC SUBSTITUENTS AS CGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-11-17 | — | — | WO | disclosed |
| CN-104470895-B | The purposes of N [3 (2 carboxy ethyl) phenyl] piperidinyl-1 yl acetamide derivatives and its activator as soluble guanylate cyclase | 拜耳制药股份公司 | 2017-04-05 | — | — | CN | disclosed |
| US-20110130445-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-02 | — | — | US | disclosed |
| WO-2011051165-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010102717-A1 | OXO-HETEROCYCLICALLY SUBSTITUTED ALKYL CARBOXYLIC ACIDS AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-16 | — | — | WO | disclosed |
| US-20090306197-A1 | Substituted Chromanol Derivatives and Their Use | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| US-20090306197-A1 | Substituted Chromanol Derivatives and Their Use | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| US-20090306197-A1 | Substituted Chromanol Derivatives and Their Use | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| CN-101443321-A | Substituted chromanol derivatives and uses thereof | BAYER HEALTHCARE AG (DE) | 2009-05-27 | — | — | CN | disclosed |
| WO-2007107243-A1 | SUBSTITUTED CHROMANOL DERIVATIVES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2007-09-27 | — | — | WO | disclosed |
| US-5428033-A | Useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotecyive agents | MERCK FROSST CANADA, INC. (CA) | 1995-06-27 | — | — | US | disclosed |
| EP-0480716-A1 | Saturated hydroxyalkylquinoline acids as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1992-04-15 | — | — | EP | disclosed |