Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 13/20 | 0.51 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5002608 | 0.86 | DAO (0.54) | PLA2G10CCR2DAOMCL1ALDH1A1 | |
| SCHEMBL30844614 | 0.86 | DAO (0.54) | PLA2G10CCR2DAOMCL1ALDH1A1 | |
| SCHEMBL4102690 | 0.81 | PLA2G10 (0.49) | PLA2G10CCR2DAOSLC9A1MCL1 | |
| SCHEMBL28678163 | 0.79 | NOD2 (0.57) | F10ALDH1A1TSHR | |
| SCHEMBL28732915 | 0.78 | PLA2G10 (0.56) | PLA2G10CCR2DAOSLC9A1MCL1 | |
| SCHEMBL19691145 | 0.74 | PLA2G10 (0.51) | PLA2G10CCR2DAOSLC9A1MCL1 | |
| SCHEMBL7958583 | 0.74 | PLA2G10 (0.51) | PLA2G10CCR2DAOMCL1F10 | |
| SCHEMBL2830160 | 0.73 | PLA2G10 (0.54) | PLA2G10CCR2DAOSLC9A1MCL1 | |
| SCHEMBL7670332 | 0.72 | DAO (0.70) | PLA2G10CCR2DAOSLC9A1MCL1 | |
| SCHEMBL4103400 | 0.72 | PLA2G10 (0.53) | PLA2G10CCR2DAOSLC9A1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797086-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006032509-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |