Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391453 | 0.76 | APOBEC3G (0.39) | APOBEC3GEPHX1PDCD1CD274CYP4F2 | |
| SCHEMBL543497 | 0.76 | EPHX1 (0.41) | APOBEC3GCYP2D6EPHX1PDCD1CD274 | |
| SCHEMBL28745945 | 0.73 | APOBEC3G (0.36) | APOBEC3GEPHX1PDCD1CD274CYP4F2 | |
| SCHEMBL30065199 | 0.73 | APOBEC3G (0.43) | APOBEC3GEPHX1PDCD1CD274CYP4F2 | |
| SCHEMBL5950358 | 0.72 | SLC6A2 (0.50) | APOBEC3GEPHX1PDCD1CD274CYP4F2 | |
| SCHEMBL6001493 | 0.69 | NFE2L2 (0.42) | SLC6A2L3MBTL1 | |
| SCHEMBL5535600 | 0.69 | SCN4A (0.42) | KDM4EMAPK1TSHR | |
| SCHEMBL194417 | 0.69 | HRH1 (0.60) | TSHRSLC6A2SLC6A4LMNAGAA | |
| SCHEMBL5547846 | 0.69 | CA1 (0.56) | GRIN1GRIN2BMAPK1TSHRL3MBTL1 | |
| SCHEMBL17820 | 0.69 | IDO1 (0.57) | GRIN1TSHRLMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745029-A1 | SUBSTITUTED MORPHOLINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Warner-Lambert Company LLC (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005105763-A1 | SUBSTITUTED MORPHOLINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |