Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.46 |
| ▸ | PPARA | Q07869 | 18/20 | 0.46 |
| ▸ | PPARG | P37231 | 10/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186720 | 0.92 | PPARD (0.38) | PPARDPPARAPPARGS1PR1S1PR3 | |
| SCHEMBL5186525 | 0.89 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL5187774 | 0.86 | MCHR1 (0.37) | — | |
| SCHEMBL5188275 | 0.86 | PPARD (0.55) | PPARDPPARAPPARG | |
| SCHEMBL5186528 | 0.85 | PPARA (0.47) | PPARDPPARAPPARG | |
| SCHEMBL5187698 | 0.85 | PPARD (0.54) | PPARDPPARAPPARG | |
| SCHEMBL5187697 | 0.84 | PPARD (0.51) | PPARDPPARAPPARG | |
| SCHEMBL5186561 | 0.82 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL5186699 | 0.82 | PPARD (0.39) | PPARDPPARAPPARG | |
| SCHEMBL5186605 | 0.82 | PPARD (0.46) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863772-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-12-12 | — | — | EP | claimed |
| WO-2007028424-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-15 | — | — | WO | claimed |
| US-20060183754-A1 | Amide bridged piphenyl or biazaphenyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | US | claimed |
| EP-1863772-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2007028424-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-15 | — | — | WO | disclosed |
| US-20060183754-A1 | Amide bridged piphenyl or biazaphenyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183754-A1 | Amide bridged piphenyl or biazaphenyl derivatives | PPARD, PPARA, PPARG | PPARD 1/4885PPARA 2/4885PPARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.