Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.39 |
| ▸ | PPARA | Q07869 | 9/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186528 | 0.92 | PPARA (0.47) | PPARDPPARAPPARGFFAR4FFAR1 | |
| SCHEMBL5188301 | 0.89 | PPARD (0.45) | PPARDPPARAPPARGFOSJUN | |
| SCHEMBL5937517 | 0.88 | PPARD (0.46) | PPARDPPARAPPARGFOSJUN | |
| SCHEMBL5186720 | 0.86 | PPARD (0.38) | PPARDPPARAPPARGFOSJUN | |
| SCHEMBL5187731 | 0.84 | MAPT (0.42) | PPARDPPARAPPARGTP53MAPT | |
| SCHEMBL5186699 | 0.84 | PPARD (0.39) | PPARDPPARAPPARGFOSJUN | |
| SCHEMBL5188300 | 0.84 | PPARD (0.43) | PPARDPPARAPPARGFOSJUN | |
| SCHEMBL5186692 | 0.83 | PPARA (0.38) | PPARDPPARAPPARGTP53MAPT | |
| SCHEMBL1549496 | 0.83 | PPARG (0.44) | PPARDPPARAPPARG | |
| SCHEMBL5187698 | 0.81 | PPARD (0.54) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863772-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2007028424-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-15 | — | — | WO | disclosed |