Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143206 | 0.88 | GRIA4 (0.44) | HDAC4HDAC6GRIA4EPHX2NR1H4 | |
| SCHEMBL2461910 | 0.88 | GRIA4 (0.44) | HDAC4HDAC6GRIA4EPHX2NR1H4 | |
| SCHEMBL14394695 | 0.88 | GRIA4 (0.44) | HDAC4HDAC6GRIA4EPHX2NR1H4 | |
| SCHEMBL5186058 | 0.86 | GRIA4 (0.57) | GRIA4EPHX2NR1H4 | |
| SCHEMBL3711628 | 0.86 | GRIA4 (0.48) | GRIA4 | |
| SCHEMBL13255710 | 0.86 | GRIA4 (0.48) | GRIA4 | |
| SCHEMBL5186190 | 0.85 | GRIA4 (0.44) | GRIA4EPHX2NR1H4CA12CA9 | |
| SCHEMBL5187928 | 0.83 | GRIA4 (0.43) | HDAC4GRIA4EPHX2NR1H4MLYCD | |
| SCHEMBL5187403 | 0.83 | HDAC4 (0.43) | HDAC4HDAC6EPHX2NR1H4CA12 | |
| SCHEMBL8294927 | 0.82 | GRIA4 (0.41) | GRIA4EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183232-B1 | MONOFLUOROALKYL DERIVATIVES | LILLY CO ELI (US) | 2007-10-03 | — | — | EP | claimed |
| US-7034045-B1 | Monofluoroalkyl derivatives | ELI LILLY AND COMPANY (US) | 2006-04-25 | — | — | US | claimed |
| EP-1183232-B1 | MONOFLUOROALKYL DERIVATIVES | LILLY CO ELI (US) | 2007-10-03 | — | — | EP | disclosed |
| EP-1183232-B1 | MONOFLUOROALKYL DERIVATIVES | LILLY CO ELI (US) | 2007-10-03 | — | — | EP | disclosed |
| US-7034045-B1 | Monofluoroalkyl derivatives | ELI LILLY AND COMPANY (US) | 2006-04-25 | — | — | US | disclosed |
| EP-1330233-B1 | METHOD OF TREATING STROKE | LILLY CO ELI (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040063680-A1 | Method of treating stroke | CLEMENS JAMES ALLEN (US) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063680-A1 | Method of treating stroke | ASAH2, PCSK7, PCSK9 | HDAC4 782/4885HDAC6 110/4885GRIA4 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.