Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 9/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14394695 | 1.00 | GRIA4 (0.44) | GRIA4PLK1EPHX2NR1H4HDAC6 | |
| SCHEMBL2143206 | 1.00 | GRIA4 (0.44) | GRIA4PLK1EPHX2NR1H4HDAC6 | |
| SCHEMBL5186058 | 0.89 | GRIA4 (0.57) | GRIA4EPHX2NR1H4 | |
| SCHEMBL3711628 | 0.88 | GRIA4 (0.48) | GRIA4CA2GRIA2CA1 | |
| SCHEMBL13255710 | 0.88 | GRIA4 (0.48) | GRIA4CA2GRIA2CA1 | |
| SCHEMBL5187397 | 0.88 | HDAC4 (0.43) | GRIA4EPHX2NR1H4HDAC6HDAC4 | |
| SCHEMBL5186190 | 0.88 | GRIA4 (0.44) | GRIA4EPHX2NR1H4CA2RORC | |
| SCHEMBL5187928 | 0.85 | GRIA4 (0.43) | GRIA4EPHX2NR1H4HDAC4PDK2 | |
| SCHEMBL8294927 | 0.84 | GRIA4 (0.41) | GRIA4EPHX2NR1H4GRIA2 | |
| SCHEMBL6561639 | 0.84 | GRIA4 (0.51) | GRIA4EPHX2NR1H4CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034196-A1 | COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR | LIFELIKE BIOMATIC INC. (US) | 2006-03-30 | — | — | WO | claimed |
| US-20060063707-A1 | Compositions for enhancing memory and methods therefor | LIFELIKE BIOMATIC, INC. (US) | 2006-03-23 | — | — | US | claimed |
| US-12064410-B2 | Compositions and methods for stimulating ventilatory and/or respiratory | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-08-20 | — | — | US | disclosed |
| EP-3316890-B1 | NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF MAKING AND USING SAME | NEURAD LTD (IL) | 2023-09-06 | — | — | EP | disclosed |
| US-20230142111-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-11 | — | — | US | disclosed |
| US-20160257957-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-09-08 | — | — | US | disclosed |
| EP-2544688-B1 | METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME | HARVARD COLLEGE (US) | 2016-09-07 | — | — | EP | disclosed |
| US-20130058915-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS | Children's Medica Center Corporation (US) | 2013-03-07 | — | — | US | disclosed |
| EP-2544688-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS | President and Fellows of Harvard College (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011109398-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-09-09 | — | — | WO | disclosed |
| US-20100069377-A1 | TREATMENT OF FEMALE SEXUAL DYSFUNCTION BY COMPOUNDS THAT POSITIVELY MODULATE AMPA-TYPE GLUTAMATE RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-18 | — | — | US | disclosed |
| WO-2008118644-A1 | TREATMENT OF FEMALE SEXUAL DYSFUNCTION BY COMPOUNDS THAT POSITIVELY MODULATE AMPA-TYPE GLUTAMATE RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2006034196-A1 | COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR | LIFELIKE BIOMATIC INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20060063707-A1 | Compositions for enhancing memory and methods therefor | LIFELIKE BIOMATIC, INC. (US) | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063707-A1 | Compositions for enhancing memory and methods therefor | GRIN1, GRIN3A, GRIN2A | GRIA4 19/4885PLK1 1493/4885EPHX2 3478/4885 |
| US-12064410-B2 | Compositions and methods for stimulating ventilatory and/or respiratory | CTH, SLC25A20, CRH | GRIA4 422/4885PLK1 3590/4885EPHX2 1632/4885 |
| US-20230142111-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS | GRIN2D, GRIN2A, GRIN2C | GRIA4 14/4885PLK1 1060/4885EPHX2 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.