Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorometholone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 11/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorometholone SCHEMBL5051 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL14769393 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL19327160 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13069233 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL9415488 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13026152 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL23975162 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13069734 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL5187733 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL3209599 | 0.96 | HIF1A (0.93) | HIF1ACYP3A4PGRNR3C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448202-A1 | COMBINATION OF A PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA Pharma AG (DE) | 2004-08-25 | — | — | EP | claimed |
| WO-2003039552-A1 | COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA PHARMA AG (DE) | 2003-05-15 | — | — | WO | claimed |
| US-20030092706-A1 | Combination | NYCOMED GMBH (DE) | 2003-05-15 | — | — | US | claimed |
| US-20070270441-A1 | Combination | ALTANA PHARMA AG (DE) | 2007-11-22 | — | — | US | disclosed |
| EP-1448202-A1 | COMBINATION OF A PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA Pharma AG (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003039552-A1 | COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA PHARMA AG (DE) | 2003-05-15 | — | — | WO | disclosed |
| US-20030092706-A1 | Combination | NYCOMED GMBH (DE) | 2003-05-15 | — | — | US | disclosed |