Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorometholone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 11/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorometholone SCHEMBL5051 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL19327160 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13069233 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL9415488 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13026152 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL23975162 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL13069734 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL5187729 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL5187733 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluorometholone SCHEMBL3209599 | 0.96 | HIF1A (0.93) | HIF1ACYP3A4PGRNR3C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-03-14 | — | — | US | disclosed |
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | RORC, RORB, RORA | NR3C1 30/4885HIF1A 1107/4885CYP3A4 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.