Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 12/20 | 0.47 |
| ▸ | PPARA | Q07869 | 9/20 | 0.47 |
| ▸ | PPARG | P37231 | 8/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187722 | 0.94 | PPARA (0.49) | PPARDPPARAPPARGESRRGMAPT | |
| SCHEMBL5188268 | 0.93 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL5188740 | 0.90 | PPARA (0.58) | PPARDPPARAPPARG | |
| SCHEMBL5203845 | 0.84 | PPARD (0.51) | PPARDPPARAPPARGMAPT | |
| SCHEMBL5187788 | 0.83 | PPARA (0.56) | PPARDPPARAPPARG | |
| SCHEMBL5186692 | 0.83 | PPARA (0.38) | PPARDPPARAPPARGMAPTTP53 | |
| SCHEMBL5187757 | 0.82 | PPARD (0.43) | PPARDPPARAPPARGEPHX2FBP1 | |
| SCHEMBL5188802 | 0.81 | MCHR1 (0.44) | PPARDPPARAPPARGMAPTTP53 | |
| SCHEMBL5188255 | 0.79 | PPARD (0.51) | PPARDPPARAPPARG | |
| SCHEMBL5648539 | 0.78 | PPARA (0.48) | PPARDPPARAPPARGEPHX2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863772-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2007028424-A1 | AMIDE DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-15 | — | — | WO | disclosed |