SCHEMBL5188474

SCHEMBL5188474

C=CC(C#N)C[C]=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18289484 0.79
SCHEMBL10891827 0.77
SCHEMBL9879686 0.74
SCHEMBL22148540 0.73 ALDH1A1 (0.32)
SCHEMBL10937979 0.69
SCHEMBL317552 0.69
SCHEMBL10937975 0.69
SCHEMBL7087574 0.69
SCHEMBL8078932 0.67
SCHEMBL570794 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1697303-A4 CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF STIEFEL LABORATORIES (US) 2007-07-04 EP disclosed
EP-1697303-A1 CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF STIEFEL LABORATORIES, INC. (US) 2006-09-06 EP disclosed
US-20060047171-A1 Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof STIEFEL LABORATORIES, INC. 2006-03-02 US disclosed
WO-2005068414-A1 CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF STIEFEL LABORATORIES, INC. (US) 2005-07-28 WO disclosed
EP-1215196-B1 Selective reductive amination of nitriles AIR PROD & CHEM (US) 2004-05-12 EP disclosed
EP-1094058-B1 Selective reductive amination of nitriles AIR PROD & CHEM (US) 2003-09-03 EP disclosed
EP-1215196-A1 Selective reductive amination of nitriles AIR PRODUCTS AND CHEMICALS, INC. (US) 2002-06-19 EP disclosed
US-6399830-B1 USING CATALYST AIR PRODUCTS AND CHEMICALS, INC. 2002-06-04 US disclosed
US-6248925-B1 REACTING A NITRILE WITH A PRIMARY OR SECONDARY AMINE EFFECTING CONVERSION OF THE NITRILE GROUP TO THE CORRESPONDING SECONDARY OR TERTIARY AMINE; PROMOTIONALLY EFFECTIVE AMOUNT OF A LITHIUM COMPOUND OR SODIUM CHLORIDE. AIR PRODUCTS AND CHEMICALS, INC. 2001-06-19 US disclosed
EP-1094058-A1 Selective reductive amination of nitriles AIR PRODUCTS AND CHEMICALS, INC. (US) 2001-04-25 EP disclosed