Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.78 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5188598 | 1.00 | P2RX7 (0.78) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL5188601 | 1.00 | P2RX7 (0.78) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL14160076 | 0.98 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223802 | 0.98 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223799 | 0.98 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223804 | 0.98 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445424 | 0.90 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445425 | 0.90 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445426 | 0.90 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL3655715 | 0.88 | P2RX7 (1.00) | P2RX7TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051441-A | Immunomodulators and cardiovascular disorders | TANABE SEIYAKU CO., LTD. (JP) | 1991-09-24 | — | — | US | claimed |
| JP-2101065-A | — | — | None | — | — | JP | disclosed |
| US-20070270441-A1 | Combination | ALTANA PHARMA AG (DE) | 2007-11-22 | — | — | US | disclosed |
| EP-1448202-A1 | COMBINATION OF A PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA Pharma AG (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003039552-A1 | COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA PHARMA AG (DE) | 2003-05-15 | — | — | WO | disclosed |
| US-20030092706-A1 | Combination | NYCOMED GMBH (DE) | 2003-05-15 | — | — | US | disclosed |
| EP-0363061-B1 | IMIDAZOLINE DERIVATIVE AND PREPARATION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1992-07-22 | — | — | EP | disclosed |
| US-5051441-A | Immunomodulators and cardiovascular disorders | TANABE SEIYAKU CO., LTD. (JP) | 1991-09-24 | — | — | US | disclosed |
| JP-H02101065-A | IMIDAZOLINE DERIVATIVE | TANABE SEIYAKU CO LTD | 1990-04-12 | — | — | JP | disclosed |
| EP-0363061-A1 | Imidazoline derivative and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1990-04-11 | — | — | EP | disclosed |