Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 6/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22059473 | 0.90 | RARB (0.69) | RARBALDH1A1MEN1KMT2ARARA | |
| SCHEMBL15093809 | 0.89 | HRH3 (0.65) | HRH3PLK1MEN1KMT2ACA12 | |
| SCHEMBL4122562 | 0.87 | MAPT (0.62) | HRH3PLK1ALDH1A1MEN1KMT2A | |
| SCHEMBL4111018 | 0.86 | TP53 (0.61) | EPHX2HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL28373605 | 0.86 | NPC1 (0.54) | RARBPLK1ALDH1A1MEN1KMT2A | |
| SCHEMBL44017 | 0.86 | RARB (0.69) | RARBPLK1ALDH1A1MEN1KMT2A | |
| SCHEMBL5188617 | 0.85 | NPC1 (0.66) | ALDH1A1MEN1KMT2AMAPTCA12 | |
| SCHEMBL4106216 | 0.84 | RAB9A (0.67) | HRH3MEN1KMT2AMAPTCA12 | |
| SCHEMBL4122892 | 0.84 | MAPT (0.64) | ALDH1A1MEN1KMT2AMAPTABCG2 | |
| Methyl Alcohol SCHEMBL38654374 | 0.84 | RARB (0.67) | RARBPLK1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | disclosed |