Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13652613 | 0.89 | GAA (0.60) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL5188518 | 0.87 | GAA (0.81) | NPC1GAAALDH1A1LMNACYP2C19 | |
| SCHEMBL18415529 | 0.87 | NPC1 (0.68) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL7959649 | 0.85 | RAB9A (0.67) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL10748359 | 0.85 | MAPT (0.72) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL13652639 | 0.85 | GAA (0.56) | NPC1RAB9AGAAHTTHSD17B10 | |
| SCHEMBL7465996 | 0.84 | GAA (0.62) | GAAALDH1A1HTTCYP2C19KMT2A | |
| SCHEMBL7959643 | 0.84 | NPC1 (0.65) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL10457597 | 0.84 | NPC1 (0.65) | NPC1RAB9AGAAALDH1A1MAPT | |
| SCHEMBL7354067 | 0.84 | GAA (0.55) | NPC1RAB9AGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | disclosed |